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Web14 apr. 2024 · The MAPK pathway is significantly increased via insulin growth factor 1 receptor (IGF1R) signaling, and treatment with an ERK inhibitor and IGF1R inhibitor restores the BRAFi sensitivity in cells lacking HAT1 . However, how HAT1 knockdown activates these pathways was not explained. WebThe IGF1R displays potent antiapoptotic, pro-survival capacities and plays a key role in malignant transformation. Research has identified the IGF1R as a candidate therapeutic … sewage pump chambers uk
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