Web25 de mai. de 2024 · 5003 Background: Patients (pts) with Von Hippel-Lindau disease (VHL) are at risk for several cancers, including clear cell renal cell carcinoma (ccRCC). Inactivation of VHL results in constitutive activation of the HIF-2α transcription factor, which drives tumor growth. MK-6482, a potent, selective, small molecule HIF-2α inhibitor, has … Web20 de jun. de 2024 · In this review, we will discuss the current understandings of hypoxia signaling in human diseases by the organ systems, including the heart, lung, liver, and …
Hypoxia-inducible factor-2alpha transactivates Abcg2 and ... - PubMed
Web3 de out. de 2024 · Disclosed are methods and compositions for treating cardiovascular diseases including cardiomyopathy and heart ... HIF-2α (or HIF-2alpha or HIF-2a) is, ... Signoretti S, Bruick R K, Josey J A, Wallace E M, Kaelin W G. On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models. Nature. 2016; 539:107-111. [0143 ... Web13 de mar. de 2024 · Hypoxia is an inherent pathophysiological characteristic of chronic kidney disease (CKD), which is closely associated with the development of renal ... Ramakrishnan S.K., et al. Hepatic hepcidin/intestinal HIF-2alpha axis maintains iron absorption during iron deficiency and overload. J Clin Investig. 2024; 129 (1):336–348. … fitgo boa
Efficacy and Safety of Daprodustat for Anemia Therapy in Chronic Kidney …
Web9 de mai. de 2008 · To further examine the molecular regulation of the Abcg2 gene, we demonstrated that hypoxia-inducible factor (HIF)-2alpha binds an evolutionary conserved HIF-2alpha response element in the murine Abcg2 promoter. Transcriptional assays reveal a dose-dependent activation of Abcg2 expression by HIF-2alpha. Web22 de nov. de 2024 · Renal fibrosis is the final manifestation of chronic kidney disease (CKD) regardless of etiology. Hypoxia-inducible factor-2 alpha (HIF-2α) is an important … WebNational Center for Biotechnology Information can hip out of alignment cause knee pain