WebMay 7, 2024 · Cancer cells are characterized as highly proliferative at the expense of enhancement of metabolic rate. Consequently, cancer cells rely on antioxidant defenses to overcome the associated increased production of reactive oxygen species (ROS). The reliance of tumor metabolism on amino acids, especially amino acid transport systems, … WebNov 17, 2024 · Depriving cancer cells of the amino acid cystine can trigger the non-apoptotic cell death process of ferroptosis. Here, we report that cancer cells can evade cystine deprivation-induced ferroptosis by uptake and catabolism of the cysteine-rich extracellular protein albumin. This protective mechanism is enhanced by mTORC1 …
Radiotherapy and Immunotherapy Promote Tumoral Lipid …
WebJun 20, 2024 · Ferroptosis is a new type of oxidative regulated cell death (RCD) driven by iron-dependent lipid peroxidation. As major sites of iron utilization and master regulators of oxidative metabolism, mitochondria are the main source of reactive oxygen species (ROS) and, thus, play a role in this type of RC … Webwww.ncbi.nlm.nih.gov higley center performing arts
Targeting ferroptosis in breast cancer - Biomarker Research
WebMar 29, 2024 · Lung cancer. Ferroptosis of lung cancer cell was first induced by erastin in the K-ras mutated A549 cells . And the following report shows that erastin sensitizes … WebApr 15, 2024 · DUBbing Ferroptosis in Cancer Cells Authors: Boyi Gan University of Texas MD Anderson Cancer Center Abstract and Figures Ferroptosis, a form of iron … WebDec 4, 2024 · For in vivo studies, NCI-H1975 cells were transplanted in the left shoulder of nude mice, and then radiosensitizing effect of erastin and glutathione concentration in the cancer were evaluated. Treatment with erastin induced ferroptosis and decreased the concentration of glutathione and GPX4 protein expression levels in the two tumor cell lines. higley center-performing arts gilbert