WebJun 7, 2005 · Cyclophilins (Enzyme Commission (EC) number 5.1.2.8) belong to a group of proteins that have peptidyl-prolyl cis-trans isomerase activity; such proteins are … WebCyclophilin A (CyPA) is an 18-kD protein. The connection between diabetic nephropathy (DN) and the secreted form of CyPA (sCyPA) has been elucidated in this study that aims …
Cyclophilin - Wikipedia
WebApr 12, 2024 · Procoagulant platelets are associated with an increased risk for thrombosis. Procoagulant platelet formation is mediated via Cyclophilin D (CypD) mediated opening of the mitochondrial permeability transition pore. Inhibiting CypD activity could therefore be an interesting approach to limiting thrombosis. In this study, we investigated the potential of … WebDec 12, 1993 · Cyclophilin is a cellular receptor for the immunosuppressive drug cyclosporin A (CsA). Cyclophilin C (CyPC) is highly expressed in murine kidney, making … mls manatee county fl
Cyclophilin D - an overview ScienceDirect Topics
WebDec 24, 2016 · The first cyclophilin (Cyp/PPIases: EC 5.2.1.8) was isolated more than three decades ago as an intracellular receptor of the immunosuppressive drug cyclosporine A (CsA) from the bovine … WebCyclophilin D, encoded by the ppif gene, is an ANT-binding mitochondrial matrix peptidylprolyl cis-trans isomerase that is the target for cyclosporin A-mediated inhibition of MPTP opening (157–160). Its normal physiological functions are not known with certainty, but may include regulation of mitochondrial Ca 2+ efflux (see below) (161). WebCyclophilins (Cyps), a subfamily of immunophilins of peptidyl-prolyl cis/trans isomerases, have been implicated in various cellular processes and involved in oxidative stress 5. … mls manatee county