Bk6 tcr
WebFeb 2, 2015 · The BK6 TCR–CD1a complex and unbound CD1a were purified by mixture of equal amounts of soluble CD1a and the BK6 TCR (24.5 μM) and by passage over a … Supplementary Figure 5 CD1a-sulfatide Tetramer Staining of Jurkat.BK6 Cells - … Supplementary Figure 1 Bk6 TCR Variable Sequence and Sds-Page From Size … Supplementary Figure 6 Collision-induced Dissociation (Cid-Ms) Analysis of Lipids … Submit Manuscript - αβ T cell antigen receptor recognition of CD1a presenting … Nature Immunology is a multidisciplinary journal that publishes papers of the … Web4X6B: Bk6 Tcr Apo Structure. PDB ID: 4X6B Download: MMDB ID: 126533: PDB Deposition Date: 2014/12/8: Updated in MMDB: 2015/03: Experimental Method: x-ray …
Bk6 tcr
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WebThe BK6 TCR bound to mammalian CD1a-endo with an affinity (dissociation constant) of 29 µM (Fig. 3c-e), and we obtained a similar value for insect-derived CD1a-endo (data not … WebAnti-Lysophosphatidylcholine TCR (clone BK6), Jurkat Cell Line (TCRJ-CQ017) All products and services are For Research Use Only and CANNOT be used in the treatment or …
WebStructure 4X6C CD1a ternary complex with lysophosphatidylcholine and BK6 TCR Assembly Asm Id 1: Author Defined Assembly Dynamic Bonds Off Nothing Focused … WebJurkat cells expressing the BK6 TCR were stained brightly by CD1a loaded with endogenous lipids (endo, Figure 3) (these endogenous lipids are derived from the mammalian HEK293 GnT1 − cells used ...
WebBK6 TCR apo structure WebSep 21, 2015 · Subtractive analysis showed that sphingomyelin was specifically excluded from lipid-CD1a-TCR complexes and blocked tetramer staining of BK6 TCR + cells, indicating that sphingomyelin is a non-permissive ligand 45, 58. This unusual pattern of TCR response to most but not all lipid ligands was explained by the ternary structure of BK6 …
WebSupplementary Figure 1 BK6-TCR variable sequence and SDS-PAGE from SEC complexation of BK6-TCR and CD1a. (a) Protein sequence for the BK6 TCR highlighting …
WebThe ectopic, left-sided TCR footprint of BK6 did not contact lipid antigens positioned within or on the right side of the CD1a platform, explaining the observed low specificity for differing CD1a ... importance of campfire in scoutingWebMar 5, 2024 · Because some of the larger autoantigens, such as sphingomyelin, can interfere with the binding of the BK6 TCR, it was postulated that those molecules that modify the roof architecture can hinder TCR recognition and, thus, act as inhibitory ligands; therefore, only their displacement by smaller lipids, such as LPC, can lead to T cell … importance of camera in filmmakingWebSSD08B208 - 800A GE牌的SSD08B208 - 800A GE产品：估价：1，规格：SSD08B208 - 800A GE，产品系列编号：SSD08B208 - 800A GE importance of calcium in bonesWebFor CD1c and CD1a, the 3C8 and BK6 TCRs essentially failed to contact the lipid ligand but did so via two distinct mechanisms. For CD1a-LPC, phosphocholine exited through the F′ -portal but sat... importance of caffeine in human nutritionWebDec 8, 2014 · 4X6B, 4X6C, 4X6D, 4X6E, 4X6F. PubMed Abstract: A central paradigm in αβ T cell-mediated immunity is the simultaneous co-recognition of antigens and antigen … literacy scheme of workWebCreative Biolabs provides Human anti-C44H86NO8P T cell receptor (BK6), pCDTCR1 product for Biopharmaceutical research,preclinical and clinical trials. importance of bus transportationWebMar 5, 2024 · T cells represent a key cellular component of defence mechanisms against pathogens and they are subdivided into two main classes based on the genes that encode their T cell receptors (TCRs), namely αβ and γδTCRs. literacy scavenger hunt